The C-terminal low-complexity domain involved in liquid-liquid phase separation is required for BRD4 function in vivo

J Mol Cell Biol. 2019 Sep 19;11(9):807-809. doi: 10.1093/jmcb/mjz037.

Authors

Chenlu Wang¹, Erhao Zhang², Fan Wu^{2

3}, Yufeng Sun², Yingcheng Wu², Baorui Tao^{2

3}, Yue Ming¹, Yuanpei Xu¹, Renfang Mao^{2

3}, Yihui Fan^{1

2}

Affiliations

¹ Department of Immunology, School of Medicine, Nantong University, Nantong 226001, China.
² Laboratory of Medical Science, School of Medicine, Nantong University, Nantong 226001, China.
³ Department of Pathophysiology, School of Medicine, Nantong University, Nantong 226001, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Gene Expression
Gene Targeting
Liquid-Liquid Extraction* / methods
Mice
Mice, Transgenic
Nuclear Proteins / chemistry
Nuclear Proteins / genetics*
Nuclear Proteins / isolation & purification*
Phenotype
Protein Domains / genetics*
Transcription Factors / chemistry
Transcription Factors / genetics*
Transcription Factors / isolation & purification*

Substances

Brd4 protein, mouse
Nuclear Proteins
Transcription Factors