Abstract
We have designed for the first time a dual-functional luminescent probe and inhibitor of neuraminidase (NA), a key influenza target. The lead iridium(iii) complex exhibited enhanced inhibition against NA compared to the FDA-approved antiviral drug, oseltamivir, and could detect NA even in the presence of an autofluorescent background.
MeSH terms
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology
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Coordination Complexes / chemical synthesis
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Coordination Complexes / chemistry
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Coordination Complexes / pharmacology*
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Humans
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Influenza, Human / drug therapy
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Iridium / chemistry
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Iridium / pharmacology*
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Luminescent Agents / chemical synthesis
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Luminescent Agents / chemistry
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Luminescent Agents / pharmacology*
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Microbial Sensitivity Tests
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Neuraminidase / antagonists & inhibitors*
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Neuraminidase / metabolism
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Orthomyxoviridae / drug effects*
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Oseltamivir / chemistry
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Oseltamivir / pharmacology
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Solutions
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Water / chemistry
Substances
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Antiviral Agents
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Coordination Complexes
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Enzyme Inhibitors
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Luminescent Agents
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Solutions
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Water
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Oseltamivir
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Iridium
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Neuraminidase