Applicability of Supraclavicular Oxygenated and Total Hemoglobin Evaluated by Near-Infrared Time-Resolved Spectroscopy as Indicators of Brown Adipose Tissue Density in Humans

Shinsuke Nirengi; Sayuri Fuse; Shiho Amagasa; Toshiyuki Homma; Ryotaro Kime; Miyuki Kuroiwa; Tasuki Endo; Naoki Sakane; Mami Matsushita; Masayuki Saito; Yuko Kurosawa; Takafumi Hamaoka

doi:10.3390/ijms20092214

Applicability of Supraclavicular Oxygenated and Total Hemoglobin Evaluated by Near-Infrared Time-Resolved Spectroscopy as Indicators of Brown Adipose Tissue Density in Humans

Int J Mol Sci. 2019 May 6;20(9):2214. doi: 10.3390/ijms20092214.

Authors

Affiliations

¹ Division of Preventive Medicine, National Hospital Organization Kyoto Medical Center, Clinical Research Institute, Kyoto 612-8555, Japan. shi.nirengi@gmail.com.
² Department of Sports Medicine for Health Promotion, Tokyo Medical University, Tokyo 160-8402, Japan. fuse@tokyo-med.ac.jp.
³ Department of Preventive Medicine and Public Health, Tokyo Medical University, Tokyo 160-8402, Japan. shiho.ama@gmail.com.
⁴ Faculty of Sports and Health Science, Daito Bunka University, Higashimatsuyama-shi, Saitama 355-8501, Japan. t-homma@ic.daito.ac.jp.
⁵ Department of Sports Medicine for Health Promotion, Tokyo Medical University, Tokyo 160-8402, Japan. kime@tokyo-med.ac.jp.
⁶ Department of Sports Medicine for Health Promotion, Tokyo Medical University, Tokyo 160-8402, Japan. mkuroiwa@tokyo-med.ac.jp.
⁷ Department of Sports Medicine for Health Promotion, Tokyo Medical University, Tokyo 160-8402, Japan. endo-tasuki-fv@ynu.jp.
⁸ Division of Preventive Medicine, National Hospital Organization Kyoto Medical Center, Clinical Research Institute, Kyoto 612-8555, Japan. nsakane@gf6.so-net.ne.jp.
⁹ Department of Nutrition, Tenshi College, Sapporo 065-0013, Japan. matsushita@tenshi.ac.jp.
¹⁰ Hokkaido University, Sapporo 060-0818, Japan. ms-consa@krf.biglobe.ne.jp.
¹¹ Department of Sports Medicine for Health Promotion, Tokyo Medical University, Tokyo 160-8402, Japan. yuko.kurosawa.2011@gmail.com.
¹² Department of Sports Medicine for Health Promotion, Tokyo Medical University, Tokyo 160-8402, Japan. kyp02504@nifty.com.

Abstract

Brown adipose tissue (BAT) may potentially be used in strategies for preventing lifestyle-related diseases. We examine evidence that near-infrared time-resolved spectroscopy (NIR_TRS) is capable of estimating human BAT density (BAT-d). The parameters examined in this study are total hemoglobin [total-Hb]_sup, oxygenated Hb [oxy-Hb]_sup, deoxygenated Hb [deoxy-Hb]_sup, Hb O₂ saturation (StO_2sup), and the reduced scattering coefficient in the supraclavicular region (μ_s'_sup), where BAT deposits can be located; corresponding parameters in the control deltoid region are obtained as controls. Among the NIR_TRS parameters, [total-Hb]_sup and [oxy-Hb]_sup show region-specific increases in winter, compared to summer. Further, [total-Hb]_sup and [oxy-Hb]_sup are correlated with cold-induced thermogenesis in the supraclavicular region. We conclude that NIR_TRS-determined [total-Hb]_sup and [oxy-Hb]_sup are useful parameters for evaluating BAT-d in a simple, rapid, non-invasive manner.

Keywords: 18F-fluorodeoxyglucose-positron emission tomography; brown adipose tissue (BAT); cold-induced thermogenesis; noninvasive; seasonal temperature fluctuations; thermogenic functional ingredients.

Publication types

Comparative Study
Validation Study

MeSH terms

Adipose Tissue, Brown / anatomy & histology
Adipose Tissue, Brown / diagnostic imaging
Adipose Tissue, Brown / physiology*
Adult
Deltoid Muscle
Female
Humans
Male
Middle Aged
Oxyhemoglobins / analysis*
Positron-Emission Tomography / standards
Sensitivity and Specificity
Spectroscopy, Near-Infrared / methods*
Spectroscopy, Near-Infrared / standards
Thermogenesis

Substances

Oxyhemoglobins

Grants and funding

15H03100/Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan