Comparison of sleep complaints and quality of life between patients with neuromyelitis optica spectrum disorder (NMOSD) and healthy controls

Mahdi Barzegar; D Sadeghi Bahmani; Nasim Nehzat; Marjan Kiani; Niloofar Hashemi; Omid Mirmosayyeb; Serge Brand; Vahid Shaygannejad

doi:10.1016/j.msard.2019.04.008

Comparison of sleep complaints and quality of life between patients with neuromyelitis optica spectrum disorder (NMOSD) and healthy controls

Mult Scler Relat Disord. 2019 Jul:32:81-87. doi: 10.1016/j.msard.2019.04.008. Epub 2019 Apr 12.

Authors

Mahdi Barzegar¹, D Sadeghi Bahmani², Nasim Nehzat³, Marjan Kiani³, Niloofar Hashemi¹, Omid Mirmosayyeb¹, Serge Brand⁴, Vahid Shaygannejad⁵

Affiliations

¹ Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran; Student Research Committee, school of medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
² Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran; University of Basel, Psychiatric Clinics, Center for Affective, Stress and Sleep Disorders, Basel, Switzerland; Kermanshah University of Medical Sciences, Sleep Disorders and Substance Abuse Prevention Research Center, Kermanshah, Iran.
³ Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
⁴ University of Basel, Psychiatric Clinics, Center for Affective, Stress and Sleep Disorders, Basel, Switzerland; Kermanshah University of Medical Sciences, Sleep Disorders and Substance Abuse Prevention Research Center, Kermanshah, Iran; University of Basel, Department of Sport, Exercise and Health, Division of Sport Sciences and Psychosocial Health, Basel, Switzerland.
⁵ Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: shaygannejad@med.mui.ac.ir.

PMID: 31063950
DOI: 10.1016/j.msard.2019.04.008

Abstract

Background: Neuromyelitis optica spectrum disorder (NMOSD) is a chronic autoimmune disorder which is associated with sleep disturbances and a lower quality of life. The aims of the study were: (1) Comparing sleep characteristics, quality of life, and symptoms of depression and anxiety between patients with NMOSD and healthy controls (HCs). (2) Predicting sleep characteristics among patients with NMOSD based on psychological and illness-related factors.

Method: A total of 41 patients with NMOSD (Mean age = 37.48 years; 73.2% f) and 46 matched HCs took part in the study. Individuals with NMOSD reported on illness duration, fatigue and EDSS scores; further, all participants completed self-rating questionnaires covering sleep quality, daytime sleepiness, symptoms of obstructive sleep apnea and restless legs syndrome, quality of life, depression and anxiety.

Results: Compared to HCs, individuals with NMOSD reported a lower quality of life, higher symptoms of anxiety and depression, and more symptoms of restless legs syndrome. Among individuals with NMOSD, longer illness duration and higher fatigue scores predicted poor sleep quality.

Conclusion: Compared to HCs, individuals with NMOSD reported poorer quality of life and higher levels of depression and anxiety. Further, among individuals with NMOSD, sleep characteristics are predicted by a complex variety of illness-related factors.

Keywords: Fatigue; Health-related quality of life; Neuromyelitis optica spectrum disorder; Restless legs syndrome; Sleep apnea; Sleep quality.

Publication types

Comparative Study

MeSH terms

Adult
Female
Healthy Volunteers
Humans
Male
Middle Aged
Neuromyelitis Optica / diagnosis*
Neuromyelitis Optica / epidemiology
Neuromyelitis Optica / psychology*
Quality of Life / psychology*
Sleep Wake Disorders / diagnosis*
Sleep Wake Disorders / epidemiology
Sleep Wake Disorders / psychology*