Unexpected Friendship: Neutrophils Help Tumor Cells En Route to Metastasis

Oihana Iriondo; Min Yu

doi:10.1016/j.devcel.2019.04.021

Unexpected Friendship: Neutrophils Help Tumor Cells En Route to Metastasis

Dev Cell. 2019 May 6;49(3):308-310. doi: 10.1016/j.devcel.2019.04.021.

Authors

Oihana Iriondo¹, Min Yu²

Affiliations

¹ Department of Stem Cell Biology and Regenerative Medicine and USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
² Department of Stem Cell Biology and Regenerative Medicine and USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: minyu@med.usc.edu.

Abstract

Circulating tumor cells (CTCs) contain metastatic precursors that can initiate new metastases. Recent work shows that association with neutrophils provides a proliferative advantage to CTCs, rendering them more competent in metastasis formation. The study identifies molecular players in CTC-neutrophil interactions, providing potential targets for disrupting formation of these deadly metastatic seeds.

Publication types

Comment

MeSH terms

Cell Cycle
Friends
Humans
Neoplastic Cells, Circulating*
Neutrophils

Abstract

Publication types

MeSH terms

Grants and funding