Structure and Absolute Configuration of Abietane Diterpenoids from Salvia clinopodioides: Antioxidant, Antiprotozoal, and Antipropulsive Activities

J Nat Prod. 2019 May 24;82(5):1207-1216. doi: 10.1021/acs.jnatprod.8b00952. Epub 2019 May 7.

Abstract

The aerial parts of Salvia clinopodioides afforded abietanes 1a, 2a, and 3 (clinopodiolides A-C), two of which possess an unusual lactol moiety at C-19-C-20, together with an icetexane named clinopodiolide D (4a). Their structures were established by spectroscopic means, mainly 1H and 13C NMR, including 1D and 2D homo- and heteronuclear experiments. The antioxidant, antiprotozoal, and antidiarrheal effects of the isolates were evaluated. Compounds 2a and 3 showed better effects than α-tocopherol in the inhibition of lipid peroxidation with IC50 (μM) = 5.9 ± 0.1 and 2.7 ± 0.2, respectively, and moderate activity in the DPPH assay. All tested compounds showed moderate antiamoebic and antigiardial activity, as well as a good antipropulsive effect.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abietanes / chemistry*
  • Abietanes / pharmacology
  • Animals
  • Antidiarrheals / pharmacology*
  • Antioxidants / pharmacology*
  • Antiprotozoal Agents / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Rats, Wistar
  • Salvia / chemistry*
  • alpha-Tocopherol / pharmacology

Substances

  • Abietanes
  • Antidiarrheals
  • Antioxidants
  • Antiprotozoal Agents
  • alpha-Tocopherol