An Epidemic of Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6 in Osaka City, Japan, in 2017

Daiki Kanbayashi; Atsushi Kaida; Yuki Hirai; Seiji P Yamamoto; Ryoko Fujimori; Megumi Okada; Hideyuki Kubo; Nobuhiro Iritani

doi:10.7883/yoken.JJID.2018.532

An Epidemic of Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6 in Osaka City, Japan, in 2017

Jpn J Infect Dis. 2019 Sep 19;72(5):334-336. doi: 10.7883/yoken.JJID.2018.532. Epub 2019 Apr 26.

Authors

Daiki Kanbayashi¹, Atsushi Kaida¹, Yuki Hirai¹, Seiji P Yamamoto¹, Ryoko Fujimori², Megumi Okada², Hideyuki Kubo¹, Nobuhiro Iritani¹

Affiliations

¹ Osaka Institute of Public Health.
² Osaka City Public Health Bureau, Osaka City Health Center.

PMID: 31061358
DOI: 10.7883/yoken.JJID.2018.532

Abstract

The second largest epidemic of hand, foot, and mouth disease since 1982 occurred in 2017, which involved 6,173 cases in Osaka City, Japan. The main causative agent was coxsackievirus A6 (CV-A6). Phylogenetic analysis revealed that the detected CV-A6 strains belonged to genetic groups A3 and A4 in clade A.

Keywords: Japan; and mouth disease; coxsackievirus A6; foot; hand; viruses.

MeSH terms

Child, Preschool
Cities / epidemiology
Enterovirus / classification*
Enterovirus / genetics
Enterovirus / isolation & purification*
Epidemics*
Female
Genotype*
Hand, Foot and Mouth Disease / epidemiology*
Humans
Infant
Japan / epidemiology
Male