Volume-of-interest (VOI) imaging is a promising strategy for dose reduction in computed tomography (CT) while retaining image quality. However, implementation of VOI-CT has been challenged by the lack of adequate hardware and the interior tomography reconstruction problem. Multiple aperture devices (MAD) are a novel filtration scheme that can achieve x-ray fluence field modulation in a compact design with small translations. In this work, we propose a general approach for VOI imaging using MADs. MAD trajectories are designed to dynamically tailor the fluence for prescribed VOI. A penalized-likelihood reconstruction algorithm is proposed for fully truncated projections extended with scout views. Physical experiments were conducted to verify the feasibility for non-centered elliptic VOIs. Image quality and dose were estimated and compared with standard fullfield protocols. The ability of MAD-based VOI imaging to retain high image quality while significantly decreasing the total dose is demonstrated, suggesting the potential for dose reduction in clinical CT applications.
Keywords: Fluence field modulation; model-based iterative reconstruction; volume-of-interest imaging.