We have formatted an assay to detect Mycobacterium tuberculosis complex infections of non-human primates. Commercially available reagents were used to elicit a specific immune response that was measured by interferon-gamma release. Initial evaluation using blood samples from Rhesus macaques experimentally infected with M tuberculosis distinguished infected versus uninfected animals.
Keywords: cell-mediated immune response (CMI); interferon-gamma release assay (IGRA); purified protein derivative-tuberculin (PPD).
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.