Spectroscopic characterization and photodynamic antimicrobial chemotherapy of phthalocyanine-silver triangular nanoprism conjugates when supported on asymmetric polymer membranes

Donovan M Mafukidze; Azole Sindelo; Tebello Nyokong

doi:10.1016/j.saa.2019.04.054

Spectroscopic characterization and photodynamic antimicrobial chemotherapy of phthalocyanine-silver triangular nanoprism conjugates when supported on asymmetric polymer membranes

Spectrochim Acta A Mol Biomol Spectrosc. 2019 Aug 5:219:333-345. doi: 10.1016/j.saa.2019.04.054. Epub 2019 Apr 24.

Authors

Donovan M Mafukidze¹, Azole Sindelo¹, Tebello Nyokong²

Affiliations

¹ Institute of Nanotechnology Innovation, Department of Chemistry, Rhodes University, PO Box 94, Grahamstown 6140, South Africa.
² Institute of Nanotechnology Innovation, Department of Chemistry, Rhodes University, PO Box 94, Grahamstown 6140, South Africa. Electronic address: t.nyokong@ru.ac.za.

PMID: 31055240
DOI: 10.1016/j.saa.2019.04.054

Abstract

Silver triangular nanoprisms were synthesized and conjugated to zinc (ZnPc) and indium (InPc) phthalocyanines prior to embedding in asymmetric membranes. Conjugation of nanoparticles increased triplet state and singlet oxygen quantum yields of the phthalocyanines as well as enhancing photodynamic antimicrobial chemotherapy (PACT) activity against bacteria (S. aureus). The ZnPc derivative showed higher PACT activity when compared to the InPc, possibly due to degradation of the latter in aqueous media.

Keywords: Photodynamic antimicrobial chemotherapy; Phthalocyanines; Polymer membranes; Silver triangular nanoprism; Singlet oxygen.