Calcium release-activated calcium modulator 1 as a therapeutic target in allergic skin diseases

Siyu Yan; Wangqing Chen; Ya Zhang; Jie Li; Xiang Chen

doi:10.1016/j.lfs.2019.05.001

Calcium release-activated calcium modulator 1 as a therapeutic target in allergic skin diseases

Life Sci. 2019 Jul 1:228:152-157. doi: 10.1016/j.lfs.2019.05.001. Epub 2019 May 2.

Authors

Siyu Yan¹, Wangqing Chen², Ya Zhang¹, Jie Li³, Xiang Chen⁴

Affiliations

¹ Department of Dermatology, Xiangya Hospital, Central South University, Changsha,Hunan, China; Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Engineering Research Center of Skin Health and Disease, Changsha, Hunan, China.
² Department of Dermatology, Xiangya Hospital, Central South University, Changsha,Hunan, China; Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, China; Institute of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
³ Department of Dermatology, Xiangya Hospital, Central South University, Changsha,Hunan, China; Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Engineering Research Center of Skin Health and Disease, Changsha, Hunan, China. Electronic address: xylijie@csu.edu.cn.
⁴ Department of Dermatology, Xiangya Hospital, Central South University, Changsha,Hunan, China; Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Engineering Research Center of Skin Health and Disease, Changsha, Hunan, China. Electronic address: chenxiangck@126.com.

PMID: 31055088
DOI: 10.1016/j.lfs.2019.05.001

Abstract

Allergic skin disease is the most common skin condition, and considerably affects patients' life quality because of its recurrence and pruritus. Numbers of studies point out that immune cells, including mast cells and T cells, play pathogenic roles in allergic skin diseases, and share similarities in the activation and secretion of cytokines. Calcium Release-Activated Calcium Modulator 1(CRACM1/ORAI1) is a subtype of Ca²⁺ membrane channel, causing Ca²⁺ influx into the cells. As a second messenger, Ca²⁺ is an essential element that regulates immune responses, especially in the development and function of T and B cells. Thus, ORAI1 is considered to participate in allergic diseases. However, the specific mechanism of ORAI1 in skin disorders is still unclear. In order to investigate the roles of ORAI1 in allergic skin disorders, we reviewed the related articles and concluded that ORAI1 could be a potential therapeutic target for allergic skin diseases.

Keywords: Allergic skin disease; Calcium influx; Immune cells; Immune-modulator; ORAI1.

Publication types

Review

MeSH terms

Animals
B-Lymphocytes / immunology
Calcium / immunology
Dermatitis, Atopic / drug therapy
Dermatitis, Atopic / immunology
Drug Discovery
Humans
Hypersensitivity / drug therapy
Hypersensitivity / immunology*
Immunity, Cellular*
Molecular Targeted Therapy
ORAI1 Protein / immunology*
Skin Diseases / drug therapy
Skin Diseases / immunology*
T-Lymphocytes / immunology
Urticaria / drug therapy
Urticaria / immunology

Substances

ORAI1 Protein
Calcium