Cryptopharmaceuticals: Increasing the Safety of Medication by a Blockchain of Pharmaceutical Products

J Pharm Sci. 2019 Sep;108(9):2838-2841. doi: 10.1016/j.xphs.2019.04.025. Epub 2019 May 2.

Abstract

The future health-care system will contain an ever expanding number of digital elements. The data stored both at a centralized health-care level and at a local, patient level (e.g., on a smartphone) will be core elements when deciding treatment strategies in a health-care scenario with Internet of things-based elements. The current way of manufacturing pharmaceutical products and related existing logistic solutions is not ready for such a revolution. One of the key challenges is cybersecurity and related robust public key infrastructure solution. This work introduces one element of a potential solution at a prototype level: the concept of cryptopharmaceuticals where pharmaceutical products are connected in a patient-specific blockchain of individual dosage units. This technology is based on the concept where each produced dosage unit has a unique information-rich pattern. A proof-of-concept smartphone application was applied to demonstrate the visualization of this blockchain at different levels. This includes the manufacturing of the individualized dosage unit, the patient view for his/her personal blockchain, and integration of these products into a health Internet of things system. This unbreakable blockchain of personal medication history will provide means to avoid counterfeit products and to enable innovative logistic solutions.

Keywords: app design; blockchain; cryptopharmaceuticals; internet of things (IoT); printed medicine; quick response (QR) codes; serialization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blockchain / standards*
  • Counterfeit Drugs / adverse effects
  • Drug-Related Side Effects and Adverse Reactions / prevention & control*
  • Fraud / prevention & control
  • Humans
  • Internet of Things / standards*
  • Mobile Applications / standards
  • Proof of Concept Study
  • Smartphone / standards
  • Technology, Pharmaceutical / standards*

Substances

  • Counterfeit Drugs