HLA-DQB105:115, an HLA-DQB105:01:01:01 variant, identified in a Singaporean Indian individual

HLA. 2019 Aug;94(2):176-177. doi: 10.1111/tan.13564. Epub 2019 May 21.

Authors

Ashminder Kaur¹, Louise Cho¹, Nezih Cereb², Py-Yu Lin³, Kuo-Liang Yang^{3

4}

Affiliations

¹ Donor Search Department, The Bone Marrow Donor Programme, Singapore.
² HLA Laboratory, Histogenetics, Histogenetics Inc., New York, New York.
³ Laboratory of Immunogenetics, Tzu Chi Cord Blood Bank, and Buddhist Tzu Chi Bone Marrow Donor Registry, Buddhist Tzu Chi Stem Cells Centre, Hualien Tzu Chi Hospital, Hualien, Taiwan.
⁴ Department of Laboratory Medicine and Biotechnology, Buddhist Tzu Chi University, Hualien, Taiwan.

PMID: 31054201
DOI: 10.1111/tan.13564

Abstract

One nucleotide substitution in codon 46 of HLA-DQB1*05:01:01:01 results in a new allele, HLA-DQB1*05:115.

Keywords: HLA-DQB1*05:115; Singaporean Indian; human leukocyte antigen; novel allele; sequence-based typing.

© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

MeSH terms

Asian People / genetics*
Base Sequence
Codon / genetics
Exons / genetics
Genetic Variation*
HLA-DQ beta-Chains / genetics*
Humans
India
Singapore

Substances

Codon
HLA-DQ beta-Chains
HLA-DQB1 antigen