Updates in the molecular epidemiology and systemic approaches to penile cancer

Urol Oncol. 2019 Jul;37(7):403-408. doi: 10.1016/j.urolonc.2019.04.012. Epub 2019 May 1.

Abstract

Penile cancer is a rare, but increasingly more common diagnosis. Although more there are more cases of penile cancer being diagnosed (the incidence is increasing), mortality (or conversely overall survival) has not changed. A detailed discussion of current treatments, along with potential therapeutic targets, and ongoing clinical trials is presented. This review gives insight to treatment strategies and novel modalities to combat a disease with sparse therapeutic options.

Keywords: Human papilloma virus; Novel therapy; Penile cancer.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use*
  • Biomarkers, Tumor / antagonists & inhibitors*
  • Biomarkers, Tumor / genetics
  • Clinical Trials as Topic
  • Humans
  • Incidence
  • Male
  • Molecular Epidemiology
  • Papillomaviridae / isolation & purification
  • Papillomavirus Infections / epidemiology*
  • Papillomavirus Infections / genetics
  • Papillomavirus Infections / therapy
  • Papillomavirus Infections / virology
  • Papillomavirus Vaccines / therapeutic use*
  • Penile Neoplasms / epidemiology*
  • Penile Neoplasms / genetics
  • Penile Neoplasms / therapy
  • Penile Neoplasms / virology
  • Risk Factors
  • Treatment Outcome

Substances

  • Antineoplastic Agents
  • Biomarkers, Tumor
  • Papillomavirus Vaccines