Heart failure in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Andrew A House; Christoph Wanner; Mark J Sarnak; Ileana L Piña; Christopher W McIntyre; Paul Komenda; Bertram L Kasiske; Anita Deswal; Christopher R deFilippi; John G F Cleland; Stefan D Anker; Charles A Herzog; Michael Cheung; David C Wheeler; Wolfgang C Winkelmayer; Peter A McCullough; Conference Participants

doi:10.1016/j.kint.2019.02.022

Heart failure in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Kidney Int. 2019 Jun;95(6):1304-1317. doi: 10.1016/j.kint.2019.02.022. Epub 2019 Apr 30.

Authors

Andrew A House¹, Christoph Wanner², Mark J Sarnak³, Ileana L Piña⁴, Christopher W McIntyre⁵, Paul Komenda⁶, Bertram L Kasiske⁷, Anita Deswal⁸, Christopher R deFilippi⁹, John G F Cleland¹⁰, Stefan D Anker¹¹, Charles A Herzog¹², Michael Cheung¹³, David C Wheeler¹⁴, Wolfgang C Winkelmayer¹⁵, Peter A McCullough¹⁶; Conference Participants

Collaborators

Conference Participants:
Ali K Abu-Alfa, Kerstin Amann, Kazutaka Aonuma, Lawrence J Appel, Colin Baigent, George L Bakris, Debasish Banerjee, John N Boletis, Biykem Bozkurt, Javed Butler, Christopher T Chan, Maria Rosa Costanzo, Ruth F Dubin, Gerasimos Filippatos, Betty M Gikonyo, Dan K Gikonyo, Roger J Hajjar, Kunitoshi Iseki, Hideki Ishii, Greg A Knoll, Colin R Lenihan, Krista L Lentine, Edgar V Lerma, Etienne Macedo, Patrick B Mark, Eisei Noiri, Alberto Palazzuoli, Roberto Pecoits-Filho, Bertram Pitt, Claudio Rigatto, Patrick Rossignol, Soko Setoguchi, Manish M Sood, Stefan Störk, Rita S Suri, Karolina Szummer, Sydney C W Tang, Navdeep Tangri, Aliza Thompson, Krishnaswami Vijayaraghavan, Michael Walsh, Angela Yee-Moon Wang, Matthew R Weir

Affiliations

¹ Division of Nephrology, Department of Medicine, Western University and London Health Sciences Centre, London, Ontario, Canada. Electronic address: andrew.house@lhsc.on.ca.
² Department of Medicine, Division of Nephrology, University Hospital of Würzburg, Würzburg, Germany.
³ Department of Medicine, Division of Nephrology, Tufts Medical Center, Boston, Massachusetts, USA.
⁴ Division of Cardiology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York, USA.
⁵ Division of Nephrology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
⁶ Department of Internal Medicine, Section of Nephrology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada; Department of Medicine, Seven Oaks General Hospital, University of Manitoba, Winnipeg, Manitoba, Canada; Department of Community Health Sciences, Seven Oaks General Hospital, University of Manitoba, Winnipeg, Manitoba, Canada.
⁷ Hennepin County Medical Center, Minneapolis, Minnesota, USA.
⁸ Section of Cardiology, Michael E. DeBakey Veteran Affairs Medical Center, Houston, Texas, USA; Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
⁹ Inova Heart and Vascular Institute, Falls Church, Virginia, USA.
¹⁰ Robertson Centre for Biostatistics and Clinical Trials, University of Glasgow, Glasgow, UK; National Heart and Lung Institute, Imperial College, London, UK.
¹¹ Division of Cardiology and Metabolism, Department of Cardiology (CVK), Charité - Universitätsmedizin Berlin, Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Berlin, Germany; Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK, German Centre for Cardiovascular Research), Charité - Universitätsmedizin Berlin, Berlin, Germany.
¹² Division of Cardiology, Department of Medicine, Hennepin County Medical Center and University of Minnesota, Minneapolis, Minnesota, USA; Chronic Disease Research Group, Minneapolis Medical Research Foundation, Minneapolis, Minnesota, USA.
¹³ KDIGO, Brussels, Belgium.
¹⁴ University College London, London, UK.
¹⁵ Selzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
¹⁶ Department of Internal Medicine, Division of Cardiology, Baylor University Medical Center, Dallas, Texas, USA; Department of Internal Medicine, Division of Cardiology, Baylor Heart and Vascular Institute, Dallas, Texas, USA. Electronic address: peteramccullough@gmail.com.

PMID: 31053387
DOI: 10.1016/j.kint.2019.02.022

Abstract

The incidence and prevalence of heart failure (HF) and chronic kidney disease (CKD) are increasing, and as such a better understanding of the interface between both conditions is imperative for developing optimal strategies for their detection, prevention, diagnosis, and management. To this end, Kidney Disease: Improving Global Outcomes (KDIGO) convened an international, multidisciplinary Controversies Conference titled Heart Failure in CKD. Breakout group discussions included (i) HF with preserved ejection fraction (HFpEF) and nondialysis CKD, (ii) HF with reduced ejection fraction (HFrEF) and nondialysis CKD, (iii) HFpEF and dialysis-dependent CKD, (iv) HFrEF and dialysis-dependent CKD, and (v) HF in kidney transplant patients. The questions that formed the basis of discussions are available on the KDIGO website http://kdigo.org/conferences/heart-failure-in-ckd/, and the deliberations from the conference are summarized here.

Keywords: cardiovascular disease; chronic kidney disease; congestive heart failure; hemodialysis; transplantation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Congresses as Topic
Glomerular Filtration Rate / physiology
Heart Failure / diagnosis
Heart Failure / epidemiology*
Heart Failure / etiology
Heart Failure / prevention & control
Humans
Incidence
Kidney Transplantation*
Prevalence
Renal Dialysis*
Renal Elimination / physiology
Renal Insufficiency, Chronic / blood
Renal Insufficiency, Chronic / complications*
Renal Insufficiency, Chronic / diagnosis
Renal Insufficiency, Chronic / therapy
Risk Factors
Stroke Volume / physiology
Urea / blood
Urea / metabolism

Substances

Urea