Laser ignition was used to operate a four-stroke, four-cylinder, multipoint fuel injection gasoline passenger car engine, replacing the engine classical ignition device. The laser ignition system was compactly built with diode end-pumped Nd:YAG/Cr4+:YAG composite ceramics, each laser spark plug delivering pulses at 1.06 μm with 4 mJ energy and 0.8 ns duration at variable repetition rate, in accordance with the engine speed. The engine was operated at constant speed-constant load condition of 2000 rpm-2 bar equivalent brake mean effective pressure, and different ignition timings, thus simulating city traffic situations. Two relative air-fuel ratios have been considered: λ~1 for the stoichiometric mixture operation and λ~1.25 for the lean mixture condition. Parameters indicating engine performance, efficiency, combustion stability, and emissions have been measured and registered when groups of 500 consecutive cycles were acquired. The engine brake power, brake specific fuel consumption, coefficient of variability for indicated mean effective pressure, initial and main combustion stage durations, as well as exhaust emissions like carbon monoxide (CO) and total unburned hydrocarbons (THC) emphasized that significant improvements can be obtained for lean air-fuel mixture operation. Increases of the nitrogen oxides emission (NOx) were measured when laser ignition was used.