Synergistic effects of combined vaccination with BCG and influenza vaccines on spatial cognition and hippocampal plasticity in rats

Brain Res Bull. 2019 Jul:149:268-278. doi: 10.1016/j.brainresbull.2019.04.025. Epub 2019 Apr 30.

Abstract

Previous study has demonstrated the neurobeneficial role of BCG and influenza vaccines. Based on this, our study concentrated on the synergistic effects on development of central nervous system by combined vaccination with BCG and influenza vaccines in rats. Our results displayed that pups combinedly vaccinated with BCG and influenza vaccines showed a significant enhance in spatial cognition, induction of LTP, hippocampal neurogenesis and morphology of dendritic spines compared with pups vaccinated with BCG solely. Furthermore, combined vaccination with BCG and influenza vaccines showed higher expression of BDNF, IGF-1, IL-4, IFN-γ and lower IL-1β, TNF-α and IL-6 than BCG. Taken together, combined vaccination with BCG and influenza vaccines presented synergistic effects on spatial cognition and hippocampal plasticity in rats.

Keywords: Cytokine; Synapse; Synergy; Th1/Th2 bias; Vaccines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • BCG Vaccine / metabolism*
  • BCG Vaccine / pharmacology
  • Brain / metabolism
  • Cognition / drug effects*
  • Cytokines / drug effects
  • Cytokines / metabolism
  • Drug Synergism
  • Female
  • Hippocampus / drug effects
  • Hippocampus / metabolism
  • Influenza Vaccines / metabolism*
  • Influenza Vaccines / pharmacology
  • Male
  • Maze Learning / physiology
  • Neurogenesis / physiology
  • Neuronal Plasticity / drug effects
  • Rats
  • Rats, Sprague-Dawley
  • Spatial Navigation / drug effects
  • Temporal Lobe / metabolism
  • Vaccination

Substances

  • BCG Vaccine
  • Cytokines
  • Influenza Vaccines