Getting in LINE with Replication

Andrea J Schorn; Rob Martienssen

doi:10.1016/j.molcel.2019.04.023

Getting in LINE with Replication

Mol Cell. 2019 May 2;74(3):415-417. doi: 10.1016/j.molcel.2019.04.023.

Authors

Andrea J Schorn¹, Rob Martienssen²

Affiliations

¹ Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
² Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA; Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. Electronic address: martiens@cshl.edu.

PMID: 31051138
DOI: 10.1016/j.molcel.2019.04.023

Abstract

Sultana et al. (2019) and Flasch et al. (2019) determined integration patterns of human LINE-1 (long interspersed element-1) retrotransposons highlighting their interaction with DNA replication guided by their 5'-TTTT/AA-3' integration motif and nucleotide biases in the genome.

Publication types

Comment

MeSH terms

Bias
Genome, Human*
Humans
Long Interspersed Nucleotide Elements
Retroelements*

Substances

Retroelements