Pluripotency on Lockdown after Deletion of Three Transcription Regulators

Jennifer A Mitchell

doi:10.1016/j.stem.2019.04.008

Pluripotency on Lockdown after Deletion of Three Transcription Regulators

Cell Stem Cell. 2019 May 2;24(5):681-683. doi: 10.1016/j.stem.2019.04.008.

Author

Jennifer A Mitchell¹

Affiliation

¹ Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada. Electronic address: ja.mitchell@utoronto.ca.

PMID: 31051130
DOI: 10.1016/j.stem.2019.04.008

Abstract

Exit from the naive pluripotent state occurs through a series of changes in the gene regulatory circuitry, allowing cells to become primed for lineage commitment. In this issue of Cell Stem Cell, Kalkan et al. (2019) show that three transcription regulators are required for naive mouse embryonic stem cells (ESCs) to exit the pluripotent state.

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MeSH terms

Animals
DNA-Binding Proteins
Gene Expression Regulation
Immunoglobulin J Recombination Signal Sequence-Binding Protein
Mice
Mouse Embryonic Stem Cells*
Pluripotent Stem Cells*
Transcription Factors

Substances

DNA-Binding Proteins
Etv5 protein, mouse
Immunoglobulin J Recombination Signal Sequence-Binding Protein
Rbpj protein, mouse
Transcription Factors