A Prospective OCT Study of Rubella Retinopathy

Jyoti Matalia; Anand Vinekar; Neha Anegondi; Shwetha Mangalesh; Hemant Anaspure; K Bhujang Shetty; Abhijit Sinha Roy

doi:10.1016/j.oret.2018.06.003

A Prospective OCT Study of Rubella Retinopathy

Ophthalmol Retina. 2018 Dec;2(12):1235-1240. doi: 10.1016/j.oret.2018.06.003. Epub 2018 Jul 17.

Authors

Jyoti Matalia¹, Anand Vinekar², Neha Anegondi³, Shwetha Mangalesh², Hemant Anaspure⁴, K Bhujang Shetty⁴, Abhijit Sinha Roy⁵

Affiliations

¹ Pediatric Ophthalmology Services, Narayana Nethralaya Eye Hospital, Bangalore, India. Electronic address: jyoti.matalia@gmail.com.
² Pediatric Retina Services, Narayana Nethralaya, Bangalore, India.
³ School of Biosciences and Technology, VIT University, Vellore, India.
⁴ Pediatric Ophthalmology Services, Narayana Nethralaya Eye Hospital, Bangalore, India.
⁵ Imaging, Biomechanics and Mathematical Modelling Solutions, Narayana Nethralaya Foundation, Bangalore, India.

PMID: 31047196
DOI: 10.1016/j.oret.2018.06.003

Abstract

Purpose: To analyze rubella retinopathy qualitatively and quantitatively in children diagnosed with congenital rubella syndrome (CRS) using a handheld spectral-domain (SD) OCT device.

Design: Prospective, cross-sectional, nonrandomized, comparative observational study in a tertiary eye care center in south India.

Participants: Cases comprised 24 eyes of 13 children diagnosed with CRS based on seropositivity with rubella retinopathy. Controls comprised 26 eyes of 13 age-matched healthy children with normal retina.

Methods: All participants underwent retinal imaging with RetCam fundus photography (Natus Medical Inc, Pleasanton, CA) and handheld SD OCT (Bioptigen, Inc., Durham, NC). The SD OCT images of both cases and controls were segmented. Retinal and choroid thickness parameters were computed.

Main outcome measures: Qualitative and quantitative changes were observed in SD OCT images of rubella retinopathy compared with those from controls.

Results: Characteristic salt-and-pepper appearance was observed on fundus photography in children with rubella compared with the healthy children. The appearance of fovea and retinal features such as foveal dip, external limiting membrane, inner segment-outer segment boundary, outer segment-retinal pigment epithelium boundary, and retinal pigment epithelium were significantly different (P < 0.05) in eyes with rubella retinopathy compared with healthy eyes Furthermore, eyes with rubella retinopathy exhibited significantly reduced central foveal thickness (P = 0.025), subfoveal outer retinal thickness (P = 0.01), and subfoveal choroid thickness (P = 0.007) compared with healthy eyes.

Conclusions: Distinct qualitative and quantitative differences were observed in the SD OCT images of eyes with rubella retinopathy compared with those from healthy eyes.