There is scarce evidence regarding the association between the consumption of vegetables and fruits and depressive symptoms in Chinese population. The purpose of this study was to ascertain the influence of vegetables and fruits consumption on depressive symptoms in a middle-aged Chinese population. This study comprised 1676 Chinese adults aged between 45 and 59 years, who participated in a Health Survey at the time of periodic checkup in the city of Linyi, Shandong Province, China. Dietary intake was assessed using a semi-quantitative food frequency questionnaire (FFQ). Depressive symptoms were assessed using the Center for Epidemiological Studies Depression (CES-D) scale. Log-binomial regression analysis was used to evaluate the association between the consumption of vegetables and fruits and depressive symptoms. A total of 53 participants (3.2%) were classified as having depressive symptoms. After adjustment for confounding variables, participants in the highest quartile of the fruits consumption and vegetables consumption had lower prevalence ratio (PR) for depressive symptoms (PR = 0.76; 95% confidence interval [CI]: 0.603-0.974, P = .042; PR = 0.77; 95% CI: 0.612-0.977, P = .045) than those in the lowest quartile. Moreover, those in the highest quartile of total vegetables and fruits consumption had also a lower PR of depressive symptoms (PR = 0.67; 95% CI: 0.503-0.806, P = .037) than did those in the lowest quartile.Our findings indicate that higher consumption of vegetables and fruits is significantly associated with a lower risk of depressive symptoms. Further prospective studies are needed to confirm these findings.