Successful Treatment of an EBV-positive Diffuse Large B-Cell Lymphoma in a Patient With Trisomy 21

J Pediatr Hematol Oncol. 2020 Aug;42(6):e472-e474. doi: 10.1097/MPH.0000000000001502.

Abstract

Diffuse large B-cell Lymphoma (DLBCL) secondary to a chronic severe Epstein-Barr virus (EBV) infection has not been previously described in a patient with trisomy 21. Here we report the case of a 14-year-old girl with trisomy 21 with impaired control of EBV and DLBCL. She was cured with dose-adapted chemotherapy and hematopoietic stem cell transplantation without severe treatment-related toxicity. We describe the first case of EBV-positive DLBCL in a patient with trisomy 21 and we propose a treatment modality for this rare entity.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Combined Modality Therapy
  • Down Syndrome / complications
  • Down Syndrome / genetics
  • Down Syndrome / therapy*
  • Down Syndrome / virology
  • Epstein-Barr Virus Infections / complications
  • Epstein-Barr Virus Infections / therapy*
  • Epstein-Barr Virus Infections / virology
  • Female
  • Hematopoietic Stem Cell Transplantation / methods*
  • Herpesvirus 4, Human / isolation & purification*
  • Humans
  • Lymphoma, Large B-Cell, Diffuse / complications
  • Lymphoma, Large B-Cell, Diffuse / genetics
  • Lymphoma, Large B-Cell, Diffuse / therapy*
  • Lymphoma, Large B-Cell, Diffuse / virology
  • Prognosis