A gold-selenium-bonded nanoprobe for real-time in situ imaging of the upstream and downstream relationship between uPA and MMP-9 in cancer cells

Mingming Luan; Mingwan Shi; Wei Pan; Na Li; Bo Tang

doi:10.1039/c9cc01454c

A gold-selenium-bonded nanoprobe for real-time in situ imaging of the upstream and downstream relationship between uPA and MMP-9 in cancer cells

Chem Commun (Camb). 2019 May 16;55(41):5817-5820. doi: 10.1039/c9cc01454c.

Authors

Mingming Luan¹, Mingwan Shi, Wei Pan, Na Li, Bo Tang

Affiliation

¹ College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China. lina@sdnu.edu.cn tangb@sdnu.edu.cn.

PMID: 31041939
DOI: 10.1039/c9cc01454c

Abstract

A novel Au-Se nanoprobe with remarkable anti-interference ability for glutathione was developed for real-time in situ monitoring of the upstream and downstream regulatory relationship between uPA and MMP-9 proteins in the pathway.

MeSH terms

Glutathione / chemistry
Gold / chemistry*
Humans
MCF-7 Cells
Matrix Metalloproteinase 9 / analysis*
Nanostructures / chemistry*
Nanostructures / ultrastructure
Neoplasms / diagnostic imaging*
Neoplasms / enzymology
Optical Imaging / methods*
Selenium / chemistry*
Urokinase-Type Plasminogen Activator / analysis*

Substances

Gold
Urokinase-Type Plasminogen Activator
Matrix Metalloproteinase 9
Glutathione
Selenium