The zebrafish: A research model to understand the evolution of vertebrate immunity

Fish Shellfish Immunol. 2019 Jul:90:215-222. doi: 10.1016/j.fsi.2019.04.067. Epub 2019 Apr 27.

Abstract

The zebrafish has unique advantages for understanding the evolution of vertebrate immunity and to model human diseases. In this review, we will firstly give an overview of the current knowledge on vertebrate innate immune receptors with special emphasis on the inflammasome and then summarize the main contribution of the zebrafish model to this field, including to the identification of novel inflammasome components and to the mechanisms involved in its activation, assembly and clearance of intracellular bacteria.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Evolution*
  • Disease Models, Animal
  • Evolution, Molecular
  • Fish Proteins / genetics*
  • Fish Proteins / metabolism
  • Immunity, Innate* / genetics
  • Models, Animal
  • Receptors, Immunologic / genetics*
  • Receptors, Immunologic / metabolism
  • Zebrafish / genetics
  • Zebrafish / immunology*
  • Zebrafish / metabolism

Substances

  • Fish Proteins
  • Receptors, Immunologic