Inhibitory effects of homoharringtonine on foot and mouth disease virus in vitro

J Med Virol. 2019 Sep;91(9):1595-1601. doi: 10.1002/jmv.25494. Epub 2019 May 29.

Abstract

Foot-and-mouth disease (FMD) is a highly contagious disease that affects cloven-hoof animals including cattle, swine, sheep, goats, and lots of wild species. Effectively control measures are urged needed. Here, we showed that homoharringtonine treatment exhibited a strong inhibitory effect against two different strains of FMDVs (O/MYA98/BY/2010 and A/GD/MM/2013) in swine kidney (IBRS-2) cells. Further experiments demonstrated that homoharringtonine did not affect virus attachment or entry. Using time-of-addition assays, we found that the antiviral activity of homoharringtonine occurred primarily during the early stage of infection. These results demonstrated that homoharringtonine might be an effective anti-FMDV drug. Further studies are required to explore the antiviral activity of homoharringtonine against FMDV replication in vivo.

Keywords: FMDV; RNA virus; antiviral; homoharringtonine; viral replication.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Cell Line
  • Foot-and-Mouth Disease / virology*
  • Foot-and-Mouth Disease Virus / drug effects*
  • Foot-and-Mouth Disease Virus / physiology
  • Homoharringtonine / chemistry
  • Homoharringtonine / pharmacology*
  • Humans
  • Molecular Structure
  • Virus Internalization
  • Virus Replication / drug effects

Substances

  • Antiviral Agents
  • Homoharringtonine