There is a growing capability to project the impacts and economic effects of climate change across multiple sectors. This information is needed to inform decisions regarding the diversity and magnitude of future climate impacts and explore how mitigation and adaptation actions might affect these risks. Here, we summarize results from sectoral impact models applied within a consistent modelling framework to project how climate change will affect 22 impact sectors of the United States, including effects on human health, infrastructure and agriculture. The results show complex patterns of projected changes across the country, with damages in some sectors (for example, labour, extreme temperature mortality and coastal property) estimated to range in the hundreds of billions of US dollars annually by the end of the century under high emissions. Inclusion of a large number of sectors shows that there are no regions that escape some mix of adverse impacts. Lower emissions, and adaptation in relevant sectors, would result in substantial economic benefits.