Antibodies Tip the Balance Towards an HIV Cure

Nancy L Haigwood; Ann J Hessell

doi:10.1016/j.it.2019.03.008

Antibodies Tip the Balance Towards an HIV Cure

Trends Immunol. 2019 May;40(5):375-377. doi: 10.1016/j.it.2019.03.008.

Authors

Nancy L Haigwood¹, Ann J Hessell²

Affiliations

¹ Pathobiology and Immunology Division, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. Electronic address: haigwoon@ohsu.edu.
² Pathobiology and Immunology Division, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

PMID: 31030743
DOI: 10.1016/j.it.2019.03.008

Abstract

Long-term drug therapy for HIV-1 infection can prevent both disease progression and virus transmission, but treatment does not eradicate the virus. A new gene therapy study (Immunity 2019;50:567-575.e5) using human antibodies shows significant promise for a functional cure in a non-human primate model.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Animals
Antibodies, Monoclonal
Dependovirus
HIV Antibodies
HIV Infections*
HIV-1 / immunology*
Humans

Substances

Antibodies, Monoclonal
HIV Antibodies

Grants and funding

P51 OD011092/OD/NIH HHS/United States