Evolutionary dynamics of carbapenem-resistant Acinetobacter baumannii circulating in Chilean hospitals

Infect Genet Evol. 2019 Sep:73:93-97. doi: 10.1016/j.meegid.2019.04.022. Epub 2019 Apr 25.

Abstract

We analyze the evolutionary dynamics of ninety carbapenem-resistant Acinetobacter baumannii (CRAB) isolates collected between 1990 and 2015 in Chile. CRAB were identified at first in an isolate collected in 2005, which harbored the ISAba1-blaOXA-69 arrangement. Later, OXA-58- and OXA-23-producing A. baumannii strains emerged in 2007 and 2009, respectively. This phenomenon was associated with variations in the epidemiology of OXA-type carbapenemases, linked to nosocomial lineages belonging to ST109, ST162, ST15 (CC15) and ST318 (CC15).

Keywords: Acinetobacter baumannii; CC15; Carbapenem-resistance; Chile; OXA-type carbapenemases; WHO's priority-pathogen.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter Infections / microbiology*
  • Acinetobacter baumannii / classification
  • Acinetobacter baumannii / drug effects*
  • Acinetobacter baumannii / genetics*
  • Carbapenems / pharmacology*
  • Cross Infection / microbiology*
  • Evolution, Molecular
  • Hospitals, Pediatric*
  • Humans
  • Phylogeny
  • beta-Lactam Resistance*

Substances

  • Carbapenems