Aptamer-decorated polydiacetylene micelles with improved targeting of cancer cells

Anaëlle Doerflinger; Nam Nguyen Quang; Edmond Gravel; Frédéric Ducongé; Eric Doris

doi:10.1016/j.ijpharm.2019.04.071

Aptamer-decorated polydiacetylene micelles with improved targeting of cancer cells

Int J Pharm. 2019 Jun 30:565:59-63. doi: 10.1016/j.ijpharm.2019.04.071. Epub 2019 Apr 25.

Authors

Anaëlle Doerflinger¹, Nam Nguyen Quang², Edmond Gravel¹, Frédéric Ducongé³, Eric Doris⁴

Affiliations

¹ Service de Chimie Bioorganique et de Marquage (SCBM), CEA, Université Paris-Saclay, 91191 Gif-sur-Yvette, France.
² Molecular Imaging Research Center (MIRCen), CEA, Université Paris-Saclay, UMR9199, 92265 Fontenay-aux-Roses, France.
³ Molecular Imaging Research Center (MIRCen), CEA, Université Paris-Saclay, UMR9199, 92265 Fontenay-aux-Roses, France. Electronic address: frederic.duconge@cea.fr.
⁴ Service de Chimie Bioorganique et de Marquage (SCBM), CEA, Université Paris-Saclay, 91191 Gif-sur-Yvette, France. Electronic address: eric.doris@cea.fr.

PMID: 31029658
DOI: 10.1016/j.ijpharm.2019.04.071

Abstract

In this study, a "click and hybridization" strategy was developed for the functionalization of polydiacetylene micelles with a targeting aptamer ligand. Decoration of the nanocarriers with an anti-Annexin A2 sequence efficiently triggered enhanced internalization of the functionalized micelles in the MCF-7 cell line, with a marked increase compared to control micelles.

Keywords: Aptamer; Click chemistry; Conjugation; Micelle; Nanomedicine.

MeSH terms

Annexin A2 / genetics*
Aptamers, Nucleotide / administration & dosage*
Biological Transport
Drug Carriers / administration & dosage*
Humans
MCF-7 Cells
Micelles*
Polyacetylene Polymer / administration & dosage*

Substances

ANXA2 protein, human
Annexin A2
Aptamers, Nucleotide
Drug Carriers
Micelles
Polyacetylene Polymer
polydiacetylene