Response of BRAF^V600E-Mutant Lung Adenocarcinoma With Brain Metastasis and Leptomeningeal Dissemination to Dabrafenib Plus Trametinib Treatment

J Thorac Oncol. 2019 May;14(5):e97-e99. doi: 10.1016/j.jtho.2018.12.027.

Authors

Gaku Yamamoto¹, Jun Sakakibara-Konishi², Tomoo Ikari¹, Hidenori Kitai¹, Hidenori Mizugaki¹, Hajime Asahina¹, Eiki Kikuchi¹, Naofumi Shinagawa¹

Affiliations

¹ First Department of Medicine, Hokkaido University Hospital, Sapporo, Japan.
² First Department of Medicine, Hokkaido University Hospital, Sapporo, Japan. Electronic address: konishj@med.hokudai.ac.jp.

PMID: 31027751
DOI: 10.1016/j.jtho.2018.12.027

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Adenocarcinoma of Lung / complications*
Adenocarcinoma of Lung / drug therapy*
Adenocarcinoma of Lung / pathology
Aged
Antineoplastic Combined Chemotherapy Protocols / pharmacology
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Brain Neoplasms / secondary*
Humans
Imidazoles / pharmacology
Imidazoles / therapeutic use*
Lung Neoplasms / complications*
Lung Neoplasms / drug therapy*
Lung Neoplasms / pathology
Male
Oximes / pharmacology
Oximes / therapeutic use*
Proto-Oncogene Proteins B-raf / genetics*
Pyridones / pharmacology
Pyridones / therapeutic use*
Pyrimidinones / pharmacology
Pyrimidinones / therapeutic use*

Substances

Imidazoles
Oximes
Pyridones
Pyrimidinones
trametinib
Proto-Oncogene Proteins B-raf
dabrafenib