Hybrid polymeric micelles self-assembled from a mixture containing poly(3,4-dihydroxy-L-Phenylalanine)-Block-poly(γ-benzyl-L-glutamate) diblock copolymer bioconjugates and silver nanoparticles were reported. A series of amphiphilic copolymers with different molecular weights were synthesized via ring-opening polymerization of α-amino acid N-carboxyanhydrides. The polymer backbone was demonstrated via proton nuclear magnetic resonance spectroscopy and Fourier-transform infrared spectroscopy. It was observed that the resulting amphiphilic copolymer can self-assemble into rod-like micelles in dimethyl formamide/ethanol mixtures as confirmed via transmission electron microscopy. In addition, the formed rod-like micelles transformed to vesicular micelles upon introducing silver nanoparticles into the amphiphilic copolymer solution. The effect of silver nanoparticles content on the vesicle formation process was also studied. Spindle-like micelles were observed sequentially before the formation of the vesicles.