Rationally designed organelle-specific thermally activated delayed fluorescence small molecule organic probes for time-resolved biological applications

Qingyang Zhang; Shengnan Xu; Meng Li; Yali Wang; Na Zhang; Yan Guan; Mingxing Chen; Chuan-Feng Chen; Hai-Yu Hu

doi:10.1039/c9cc00898e

Rationally designed organelle-specific thermally activated delayed fluorescence small molecule organic probes for time-resolved biological applications

Chem Commun (Camb). 2019 May 9;55(39):5639-5642. doi: 10.1039/c9cc00898e.

Authors

Qingyang Zhang¹, Shengnan Xu, Meng Li, Yali Wang, Na Zhang, Yan Guan, Mingxing Chen, Chuan-Feng Chen, Hai-Yu Hu

Affiliation

¹ State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 1 Xian Nong Tan Street, Beijing, 100050, China. haiyu.hu@imm.ac.cn.

PMID: 31025673
DOI: 10.1039/c9cc00898e

Abstract

Two organelle-specific small molecule organic thermally activated delayed fluorescence (TADF) probes were developed, which exhibited the longest average fluorescence lifetime in time-resolved fluorescence imaging studies of cells among so far reported TADF probes.

MeSH terms

Biocompatible Materials / chemical synthesis
Biocompatible Materials / chemistry
Biocompatible Materials / pharmacology
Cell Survival / drug effects
Ethylamines / chemical synthesis
Ethylamines / chemistry*
Ethylamines / pharmacology
Hep G2 Cells
Humans
Microscopy, Confocal*
Organophosphorus Compounds / chemical synthesis
Organophosphorus Compounds / chemistry*
Organophosphorus Compounds / pharmacology
Oxygen / chemistry
Quantum Theory
Spectrometry, Fluorescence
Temperature

Substances

Biocompatible Materials
Ethylamines
Organophosphorus Compounds
Oxygen
ethylamine