Steroid-resistant eosinophilic fasciitis successfully treated with addition of extracorporeal photopheresis

Dermatol Ther. 2019 Jul;32(4):e12926. doi: 10.1111/dth.12926. Epub 2019 Apr 25.

Abstract

Eosinophilic fasciitis (EF) is an uncommon fibrosing disease of the fascia with characteristic cutaneous and hematologic manifestations. Although EF is most commonly treated with corticosteroids at the beginning, a considerable number of patients show an inadequate response and hence various therapeutic strategies have been tried, including extracorporeal photopheresis (ECP). We describe the case of a 66-year-old woman with steroid-resistant EF that improved significantly after ECP was added to her treatment regimen. To date, only six cases of this therapeutic strategy have been reported in English literature.

Keywords: eosinophilic fasciitis; extracorporeal Photopheresis; treatment.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Eosinophilia / physiopathology
  • Eosinophilia / therapy*
  • Fasciitis / physiopathology
  • Fasciitis / therapy*
  • Female
  • Glucocorticoids / administration & dosage*
  • Humans
  • Photopheresis / methods*
  • Treatment Outcome

Substances

  • Glucocorticoids

Supplementary concepts

  • Eosinophilic Fasciitis