Boron-doped diamond (BDD) electrodes present several notable properties, such as the largest potential window of all electrode materials (especially in anodic potentials), low background and capacitive currents, reduced fouling compared to other electrodes, mechanical robustness, and good stability over time. On the other hand, flow-based systems are known as well-established approaches to minimize reagent consumption and waste generation and with good compromise between sample throughput and analytical performance (mechanization of chemical assays). This review focuses on the use of BDD electrodes for electrochemical detection in flow systems, such as flow injection analysis (FIA), batch injection analysis (BIA), high performance liquid chromatography (HPLC), and capillary electrophoresis (CE). The discussion deals with the historical evolution of BDD, types of electrochemical pre-treatments (cathodically/H-terminated or anodically/O-terminated), cell configurations, and analytical performance. Articles are discussed in chronological order and subdivided according to the type of flow system: FIA, BIA, HPLC, and CE.
Keywords: batch injection analysis; capillary electrophoresis; flow injection analysis; liquid chromatography; review.