Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape

Svetlana S Sakhnevych; Inna M Yasinska; Elizaveta Fasler-Kan; Vadim V Sumbayev

doi:10.3389/fphar.2019.00342

Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape

Front Pharmacol. 2019 Apr 5:10:342. doi: 10.3389/fphar.2019.00342. eCollection 2019.

Authors

Svetlana S Sakhnevych¹, Inna M Yasinska¹, Elizaveta Fasler-Kan^{2

3}, Vadim V Sumbayev¹

Affiliations

¹ Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham, United Kingdom.
² Department of Pediatric Surgery and Department of Biomedical Research, Children's Hospital, Inselspital, University of Bern, Bern, Switzerland.
³ Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.

Abstract

The Tim-3-galectin-9 secretory pathway is known to protect various types of cancer cells against host immune surveillance. We found that pharmacologically induced mitochondrial dysfunction leads to a reduced galectin-9 expression/exocytosis in human colorectal cancer cells and re-distribution of this protein (the effect described for various cellular proteins) into mitochondria.

Keywords: Tim-3; colorectal cancer; galectin-9; immune surveillance; mitochondria.