Three new meroterpenoids from culture broth of Perenniporia medulla-panis and their antioxidant activities

Ji-Yul Kim; E-Eum Woo; Lee Su Ha; Dae-Won Ki; In-Kyoung Lee; Bong-Sik Yun

doi:10.1038/s41429-019-0184-x

Three new meroterpenoids from culture broth of Perenniporia medulla-panis and their antioxidant activities

J Antibiot (Tokyo). 2019 Aug;72(8):625-628. doi: 10.1038/s41429-019-0184-x. Epub 2019 Apr 25.

Authors

Ji-Yul Kim¹, E-Eum Woo¹, Lee Su Ha¹, Dae-Won Ki¹, In-Kyoung Lee¹, Bong-Sik Yun²

Affiliations

¹ Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan-si, Korea.
² Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan-si, Korea. bsyun@jbnu.ac.kr.

PMID: 31024078
DOI: 10.1038/s41429-019-0184-x

Abstract

Three new meroterpenoids (1-3) together with one known compound (4) were isolated from the culture broth of Perenniporia medulla-panis, a wood-rotting fungus in the family Polyporaceae. Their structures were elucidated by NMR and HRESIMS analyses. These compounds exhibited antioxidant activity with IC₅₀ values ranging from 12.8 to 190.3 μM in the 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical-scavenging assay.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antioxidants / isolation & purification*
Antioxidants / pharmacology*
Benzothiazoles / chemistry
Culture Media
Free Radical Scavengers / isolation & purification
Free Radical Scavengers / pharmacology
Magnetic Resonance Spectroscopy
Molecular Structure
Polyporaceae / chemistry*
Spectrometry, Mass, Electrospray Ionization
Sulfonic Acids / chemistry
Terpenes / isolation & purification*
Terpenes / pharmacology*

Substances

Antioxidants
Benzothiazoles
Culture Media
Free Radical Scavengers
Sulfonic Acids
Terpenes
2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid