Intestinal organoids to model cystic fibrosis

Eur Respir J. 2019 Jul 4;54(1):1802379. doi: 10.1183/13993003.02379-2018. Print 2019 Jul.

Authors

Peter van Mourik¹, Jeffrey M Beekman^{1

2}, Cornelis K van der Ent¹

Affiliations

¹ Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
² Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

PMID: 31023844
DOI: 10.1183/13993003.02379-2018

No abstract available

MeSH terms

Animals
Biological Assay / methods
Cystic Fibrosis / diagnosis
Cystic Fibrosis / genetics
Cystic Fibrosis / pathology*
Cystic Fibrosis Transmembrane Conductance Regulator / analysis*
Cystic Fibrosis Transmembrane Conductance Regulator / genetics
Cystic Fibrosis Transmembrane Conductance Regulator / metabolism
Humans
Intestinal Mucosa / metabolism
Intestinal Mucosa / pathology*
Mutant Proteins / analysis
Mutant Proteins / genetics
Mutant Proteins / metabolism
Organoids / metabolism
Organoids / pathology*
Primary Cell Culture / methods

Substances

Mutant Proteins
Cystic Fibrosis Transmembrane Conductance Regulator