Bioinspired aerogel based on konjac glucomannan and functionalized carbon nanotube for controlled drug release

Abstract

In this study, a facile marine bioinspired surface modification approach for carboxyl-functionalized multiwalled carbon nanotube (CCNT) and enhanced interfacial adhesion with the konjac glucomannan (KGM) matrix were illustrated to develop aerogels. Combined with FT-IR, XRD, Raman, TGA, XPS and SEM results, it was indicated that functionalized CCNT (PCCNT) is a reinforcer through hydrogen bond interactions in the aerogel formation process, which could be the main reason for the enhancement. The swelling and vitro release behavior of KGM/PCCNT aerogels were studied under two conditions using the drug 5-fluorouracil (5-FU). The release amount of 5-FU incorporated into KGM/PCCNT4 aerogel was about 48% at pH 1.2 and 62% at pH 6.8 after11 h, respectively. The results showed that the release rate of 5-FU from the KGM/PCCNT4 aerogel using PCCNT could be effectively controlled, suggesting potential applications for it as a drug carrier in targeted delivery in the biomedical filed.

Keywords: Aerogel; Carbon nanotubes; Controlled release; Konjac glucomannan; Poly(dopamine).