AnABlast: Re-searching for Protein-Coding Sequences in Genomic Regions

Methods Mol Biol. 2019:1962:207-214. doi: 10.1007/978-1-4939-9173-0_12.

Abstract

AnABlast is a computational tool that highlights protein-coding regions within intergenic and intronic DNA sequences which escape detection by standard gene prediction algorithms. DNA sequences with small protein-coding genes or exons, complex intron-containing genes, or degenerated DNA fragments are efficiently targeted by AnABlast. Furthermore, this algorithm is particularly useful in detecting protein-coding sequences with nonsignificant homologs to sequences in databases. AnABlast can be executed online at http://www.bioinfocabd.upo.es/anablast/ .

Keywords: Coding DNA sequences; Fossil DNA sequences; Gene finding; In silico annotation tool; Small genes.

MeSH terms

  • Algorithms*
  • Computational Biology / methods
  • Databases, Genetic
  • Exons
  • Genome*
  • Genomics
  • Internet
  • Introns
  • Molecular Sequence Annotation
  • Open Reading Frames / genetics*
  • Pseudogenes