Abstract
Infection with helminths can protect against the development of autoimmune diseases and this has been associated with induction of anti-inflammatory innate immune responses and Tregs. Here, we demonstrate that helminth-derived products can directly target T cells, especially IL-17-secreting γδ T cells that play a key pathogenic role in CNS autoimmune disease.
Keywords:
Experimental autoimmune encephalomyelitis; Fasciola hepatica; IL-17; Th17; γδ T cell.
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, Helminth / immunology
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Cell Extracts / immunology
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Cells, Cultured
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Cytokines / metabolism
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Disease Models, Animal
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Encephalomyelitis, Autoimmune, Experimental / therapy*
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Fasciola hepatica / immunology*
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Fascioliasis / immunology*
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Humans
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Immunosuppression Therapy
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Mice
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Multiple Sclerosis / therapy*
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Myelin-Oligodendrocyte Glycoprotein / immunology
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Receptors, Antigen, T-Cell, gamma-delta / metabolism
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T-Lymphocytes, Regulatory / immunology*
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Th17 Cells / immunology*
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Therapy with Helminths / methods*
Substances
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Antigens, Helminth
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Cell Extracts
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Cytokines
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Myelin-Oligodendrocyte Glycoprotein
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Receptors, Antigen, T-Cell, gamma-delta