Oxytrodiflavanone A and Oxytrochalcoflavanones A,B: New Biflavonoids from Oxytropis chiliophylla

Molecules. 2019 Apr 13;24(8):1468. doi: 10.3390/molecules24081468.

Abstract

Three previously undescribed biflavonoids, oxytrodiflavanone A (1), and oxytrochalcoflavanones A,B (2,3), were isolated from the aerial part of Oxytropis chiliophylla, together with their putative biosynthetic monomers, i.e., (2S)-5,7-dihydroxyflavanone (4), (2S)-7-hydroxyflavanone (5), and 2',4'-dihydroxychalcone (6). The structures of these compounds were elucidated by a combination analysis of spectroscopic data. The cytotoxic activities of all the isolated compounds against PC-3 human prostate cancer cell line are also presented.

Keywords: Oxytropis; Oxytropis chiliophylla; biflavonoids.

MeSH terms

  • Antineoplastic Agents, Phytogenic* / chemistry
  • Antineoplastic Agents, Phytogenic* / pharmacology
  • Biflavonoids* / chemistry
  • Biflavonoids* / pharmacology
  • Chalcones* / chemistry
  • Chalcones* / pharmacology
  • Flavanones* / chemistry
  • Flavanones* / pharmacology
  • Humans
  • Male
  • Oxytropis / classification*
  • PC-3 Cells
  • Prostatic Neoplasms / drug therapy*
  • Prostatic Neoplasms / metabolism
  • Prostatic Neoplasms / pathology

Substances

  • Antineoplastic Agents, Phytogenic
  • Biflavonoids
  • Chalcones
  • Flavanones
  • 2',4'-dihydroxychalcone
  • 7-hydroxyflavanone