Abstract
We developed biocompatible ATP responsive DNA nanogels, by grafting DNA strands on carboxymethyl chitosan polymer chains, and then hybridizing with ATP aptamers to form core-shell nanogels. The DNA duplex structure could embed DOX in the G-C sequences, and realize simultaneous sol-gel transition and DOX release when suffering enrich ATP in tumor cells.
MeSH terms
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A549 Cells
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Adenosine Triphosphate / metabolism*
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / metabolism
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Biocompatible Materials / chemistry*
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Biological Transport
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DNA / chemistry*
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Doxorubicin / chemistry
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Doxorubicin / metabolism
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Drug Carriers / chemistry*
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Drug Liberation
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Gels
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Humans
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Intracellular Space / metabolism
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Nanostructures / chemistry*
Substances
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Antineoplastic Agents
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Biocompatible Materials
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Drug Carriers
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Gels
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Doxorubicin
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Adenosine Triphosphate
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DNA