Methodology of drug screening and target identification for new necroptosis inhibitors

Pengchao Pan; Zhenyu Cai; Chunlin Zhuang; Xiaofei Chen; Yifeng Chai

doi:10.1016/j.jpha.2018.11.002

Methodology of drug screening and target identification for new necroptosis inhibitors

J Pharm Anal. 2019 Apr;9(2):71-76. doi: 10.1016/j.jpha.2018.11.002. Epub 2018 Nov 27.

Authors

Pengchao Pan¹, Zhenyu Cai², Chunlin Zhuang³, Xiaofei Chen¹, Yifeng Chai¹

Affiliations

¹ Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
² National Center for Liver Cancer, Second Military Medical University, 366 Qianju Road, Shanghai 201805, China.
³ Research Center for Marine Drugs, and Department of Pharmacology, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.

Abstract

Apoptosis has been considered as the only form of regulated cell death for a long time. However, a novel form of programmed cell death called necroptosis was recently reported. The process of necroptosis is regulated and plays a critical role in the occurrence and development of multiple human diseases. Thus, the study on the molecular mechanism of necroptosis and its effective inhibitors has been an attractive field for researchers. Herein, we introduce the molecular mechanism of necroptosis and focus on the literature about necroptosis drug screening in recent years. In addition, the identification of the critical drug targets of the necroptosis is also discussed.

Keywords: Drug screening; Inhibitors; Necroptosis; Review; Target identification.

Publication types

Review