Psoriasis Pathogenesis: Keratinocytes Are Back in the Spotlight

Natalie Garzorz-Stark; Kilian Eyerich

doi:10.1016/j.jid.2019.01.026

Psoriasis Pathogenesis: Keratinocytes Are Back in the Spotlight

J Invest Dermatol. 2019 May;139(5):995-996. doi: 10.1016/j.jid.2019.01.026. Epub 2019 Apr 19.

Authors

Natalie Garzorz-Stark¹, Kilian Eyerich²

Affiliations

¹ Department of Dermatology and Allergy, Technical University of Munich, Biedersteiner Munich, Germany.
² Department of Dermatology and Allergy, Technical University of Munich, Biedersteiner Munich, Germany. Electronic address: kilian.eyerich@tum.de.

PMID: 31010530
DOI: 10.1016/j.jid.2019.01.026

Abstract

Psoriasis is a T helper type 17-mediated immune disease. Initial triggers that lead to T helper type 17 production and inflammatory cell recruitment into skin are being delineated. Autoantigens that stimulate T helper type 17 cells are also being identified. A new and important piece of the puzzle indicates that keratinocytes not only amplify inflammation, but that they are essential for a full-blown IL-17-mediated psoriatic phenotype in mice.

Publication types

Comment

MeSH terms

Animals
Imiquimod
Interleukin-17
Keratinocytes*
Mice
Psoriasis*
Skin

Substances

Interleukin-17
Imiquimod