Urinary citrate: helpful to predict acid retention in CKD patients?

Caroline Prot-Bertoye; Marion Vallet; Pascal Houillier

doi:10.1016/j.kint.2019.01.019

Urinary citrate: helpful to predict acid retention in CKD patients?

Kidney Int. 2019 May;95(5):1020-1022. doi: 10.1016/j.kint.2019.01.019.

Authors

Caroline Prot-Bertoye¹, Marion Vallet², Pascal Houillier³

Affiliations

¹ INSERM UMRS 1138, Centre de Recherche des Cordeliers, Paris, France; CNRS, ERL 8228, Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Physiologie, Paris, France; Université Paris Descartes, Paris, France.
² Service des Explorations Fonctionnelles Physiologiques, CHU de Toulouse, Toulouse, France.
³ INSERM UMRS 1138, Centre de Recherche des Cordeliers, Paris, France; CNRS, ERL 8228, Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Physiologie, Paris, France; Université Paris Descartes, Paris, France. Electronic address: pascal.houillier@aphp.fr.

PMID: 31010475
DOI: 10.1016/j.kint.2019.01.019

Abstract

Acid retention occurs early during the course of chronic kidney disease (CKD). Studies conducted in patients with CKD suggest that alkali supplementation may slow CKD progression. However, the diagnosis of acid retention is challenging when plasma bicarbonate concentration is still normal. In this issue, Goraya et al. suggest that urinary citrate may predict acid retention in eubicarbonatemic patients with stages 1 and 2 CKD . Although interesting, this claim yet requires confirmation by further studies.

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MeSH terms

Acidosis*
Citrates
Citric Acid
Humans
Kidney
Renal Insufficiency, Chronic*

Substances

Citrates
Citric Acid