Multiclass linear discriminant analysis with ultrahigh-dimensional features

Biometrics. 2019 Dec;75(4):1086-1097. doi: 10.1111/biom.13065. Epub 2019 Jun 18.

Abstract

Within the framework of Fisher's discriminant analysis, we propose a multiclass classification method which embeds variable screening for ultrahigh-dimensional predictors. Leveraging interfeature correlations, we show that the proposed linear classifier recovers informative features with probability tending to one and can asymptotically achieve a zero misclassification rate. We evaluate the finite sample performance of the method via extensive simulations and use this method to classify posttransplantation rejection types based on patients' gene expressions.

Keywords: Fisher's multiclass discriminant analysis; jointly informative features; marginally informative features; multivariate screening; ultrahigh-dimensional classification.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Algorithms
  • Biometry
  • Classification / methods*
  • Computer Simulation
  • Discriminant Analysis*
  • Graft Rejection / genetics
  • Humans
  • Linear Models
  • Probability
  • Transcriptome