Effects of the ingestion of different kinds of white grape juice (Vitis labrusca) during adolescence on body weight, biochemical parameters and oxidative stress in liver of adult Wistar rats

Food Chem. 2019 Sep 1:291:110-116. doi: 10.1016/j.foodchem.2019.03.122. Epub 2019 Mar 25.

Abstract

The objective of this study was to evaluate the effects of the ingestion of different white grape juices: organic, conventional and conventional grape juice with 5% lemon juice during adolescence on biochemical serum profile and oxidative stress level in liver of adult Wistar rats. The phenolic and vitamin C composition of the juices were evaluated. During 32 days the rats were treated with the juices or oral water (gavage) for at a dose of 7 μL/g body weight. The animals were divided into 4 groups (n = 16/each). In the end, half of the animals received an intraperitoneal CCl4 injection of 3.0 mL/kg; the other ones received mineral oil. After euthanasia, biochemical parameters were evaluated in serum and oxidative stress in the liver. It is possible to emphasize that the juices have different phenolic and vitamin C contents. The juice consumption didn't alter the weight body and biochemical parameters in adult life.

Keywords: Carbon tetrachloride; Vitamin C; White grape juice.

MeSH terms

  • Animals
  • Antioxidants / chemistry
  • Antioxidants / metabolism
  • Antioxidants / pharmacology
  • Ascorbic Acid / analysis
  • Body Weight / drug effects
  • Carbon Tetrachloride / toxicity
  • Chromatography, High Pressure Liquid
  • Fruit and Vegetable Juices / analysis*
  • Liver / drug effects
  • Liver / metabolism*
  • Male
  • Oxidative Stress / drug effects
  • Phenols / analysis
  • Phenols / pharmacology
  • Rats
  • Rats, Wistar
  • Superoxide Dismutase
  • Vitis / chemistry*
  • Vitis / metabolism

Substances

  • Antioxidants
  • Phenols
  • Carbon Tetrachloride
  • Superoxide Dismutase
  • Ascorbic Acid