Objective: To analyze the heritability of diabetes among the Chinese twin adults. Methods: A total of 10 253 same-sex twin pairs aged 25 years and older, were selected from the Chinese National Twin Registry (CNTR) program. Heritability of diabetes was calculated by using the structural equation model. Results: After adjusted for age and gender, the overall heritability rates of diabetes were 0.41 (0.15-0.75), 0.83 (0.72-0.91) and 0.34 (0.04-0.73) in the <45 and ≥45 years twin pairs, respectively. After adjusted for age, rates of heritability appeared as 0.37 (0.05-0.78) and 0.88 (0.79-0.94) in men and women, respectively. Conclusions: Diabetes is affected by both genetic and environmental factors. The genetic effect of diabetes seemed stronger on female than that on male twins but was dying down along with ageing.
目的： 分析中国成年双生子人群的糖尿病遗传度。 方法： 利用中国双生子登记系统9省市的10 253对同性别双生子进行面访式问卷调查的相关信息，通过结构方程模型计算糖尿病的遗传度。 结果： 调整年龄和性别后，糖尿病的遗传度为0.41（0.15~0.75）；进一步亚组分析显示，<45和≥45岁组的遗传度分别为0.83（0.72~0.91）和0.34（0.04~0.73），男、女性的遗传度分别为0.37（0.05~0.78）和0.88（0.79~0.94）。 结论： 糖尿病受遗传和环境因素的共同影响，女性双生子糖尿病的遗传效应高于男性，年龄越大，遗传效应越小。.
Keywords: Diabetes mellitus; Heritability; Twin study.