Perioperative Morbidity of Gastrectomy During CRS-HIPEC: An ACS-NSQIP Analysis

Anghela Z Paredes; Francisco A Guzman-Pruneda; Sherif Abdel-Misih; John Hays; Mary E Dillhoff; Timothy M Pawlik; Jordan M Cloyd

doi:10.1016/j.jss.2019.03.036

Perioperative Morbidity of Gastrectomy During CRS-HIPEC: An ACS-NSQIP Analysis

J Surg Res. 2019 Sep:241:31-39. doi: 10.1016/j.jss.2019.03.036. Epub 2019 Apr 17.

Authors

Anghela Z Paredes¹, Francisco A Guzman-Pruneda¹, Sherif Abdel-Misih¹, John Hays², Mary E Dillhoff¹, Timothy M Pawlik¹, Jordan M Cloyd³

Affiliations

¹ Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio.
² Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio.
³ Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio. Electronic address: jordan.cloyd@osumc.edu.

PMID: 31004870
DOI: 10.1016/j.jss.2019.03.036

Abstract

Background: Formal gastrectomy is occasionally required to achieve complete cytoreduction for patients with peritoneal surface malignancies. In addition, the role of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with gastric cancer is increasingly being explored. Nevertheless, data on the safety of gastrectomy at the time of CRS-HIPEC are limited.

Methods: The American College of Surgeons-National Surgical Quality Improvement Program databases from 2005 to 2016 were used to identify patients who underwent CRS-HIPEC. Demographic, clinical, and perioperative outcomes were compared between patients who underwent CRS-HIPEC with and without gastrectomy.

Results: Among 1168 patients who underwent CRS-HIPEC, 43 (4%) underwent partial (n = 20) or total (n = 23) gastrectomy. Patients who underwent gastrectomy at the time of CRS-HIPEC had a longer operative time (529.3 versus 457.6 min, P = 0.004), were more likely to need an intraoperative transfusion (32.6% versus 14.3%, P = 0.001), experienced a longer length of stay (19.0 versus 11.3 d, P < 0.001), and had a significantly greater complication rate (60.5% versus 27.9%, P < 0.001), whereas postoperative mortality was not statistically significantly different (4.7% versus 1.4%, P = 0.09). On multivariate logistic regression, gastrectomy (odds ratio [OR] 3.52, P < 0.001) was the strongest predictor of postoperative morbidity, in addition to American Society of Anesthesiologists class 4 (OR 2.82, P = 0.001), malnutrition (OR 1.63, P = 0.01), liver resection (OR 1.88, P = 0.01), and colectomy (OR 2.04, P < 0.001).

Conclusions: Patients undergoing gastrectomy at the time of CRS-HIPEC experience a substantial postoperative complication rate (60%) and extended length of stay (mean 19 d). These findings highlight the need for cautious patient selection and preoperative counseling before performing concomitant gastrectomy and CRS-HIPEC.

Keywords: Carcinomatosis; Gastrectomy; HIPEC; Outcomes; Peritoneal surface malignancy; Reoperation.

MeSH terms

Adult
Aged
Combined Modality Therapy / adverse effects
Combined Modality Therapy / methods
Cytoreduction Surgical Procedures / adverse effects*
Cytoreduction Surgical Procedures / methods
Databases, Factual / statistics & numerical data
Female
Gastrectomy / adverse effects*
Humans
Hyperthermia, Induced / adverse effects*
Hyperthermia, Induced / methods
Length of Stay / statistics & numerical data
Male
Middle Aged
Operative Time
Peritoneal Neoplasms / therapy*
Postoperative Complications / epidemiology*
Postoperative Complications / etiology
Prospective Studies
United States / epidemiology