Polysaccharide and polypeptide based injectable thermo-sensitive hydrogels for local biomedical applications

Haile Fentahun Darge; Abegaz Tizazu Andrgie; Hsieh-Chih Tsai; Juin-Yih Lai

doi:10.1016/j.ijbiomac.2019.04.131

Polysaccharide and polypeptide based injectable thermo-sensitive hydrogels for local biomedical applications

Int J Biol Macromol. 2019 Jul 15:133:545-563. doi: 10.1016/j.ijbiomac.2019.04.131. Epub 2019 Apr 18.

Authors

Haile Fentahun Darge¹, Abegaz Tizazu Andrgie¹, Hsieh-Chih Tsai², Juin-Yih Lai³

Affiliations

¹ Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 106, Taiwan.
² Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 106, Taiwan; Advanced Membrane Materials Research Center, National Taiwan University of Science and Technology, Taipei 106, Taiwan. Electronic address: h.c.tsai@mail.ntust.edu.tw.
³ Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 106, Taiwan; Advanced Membrane Materials Research Center, National Taiwan University of Science and Technology, Taipei 106, Taiwan; R&D Center for Membrane Technology, Chung Yuan Christian University, Chungli, Taoyuan 320, Taiwan.

PMID: 31004630
DOI: 10.1016/j.ijbiomac.2019.04.131

Abstract

Injectable thermo-responsive hydrogels have been studied for various biomedical applications including; drug delivery, cell encapsulation, and tissue repairing. There are various natural and synthetic polymers which exhibit homogenous injectable solution at ambient temperature and form a gel in human body temperature. Polysaccharide, polypeptide and other biological macromolecule based hydrogels have been getting immense attention in biomedical application due to their low immunogenicity, abundance in nature, high biocompatibility and biodegradability. This manuscript focuses on polysaccharide and polypeptide based thermo-sensitive hydrogels, and some synthetic polymers which forms in situ gel in response to temperature change from ambient to body temperature. The value of numerous reactive functional groups of biological macromolecular polymers has been discussed for effortless modification and design of bio-macromolecule based thermo-sensitive hydrogels. In addition, we emphasized on the basic mechanisms of the thermo-response processes, the strategies to optimize the desired properties and their applications in local delivery approach.

Keywords: Biomacromolecule; Injectable thermo-sensitive hydrogel; Local delivery.

Publication types

Review

MeSH terms

Biocompatible Materials / chemistry*
Biocompatible Materials / pharmacology
Humans
Hydrogels / chemistry*
Hydrogels / pharmacology
Injections
Peptides / chemistry*
Polysaccharides / chemistry*
Temperature*

Substances

Biocompatible Materials
Hydrogels
Peptides
Polysaccharides